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Can I read Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence on EtoBox?
Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence by Fulong Wen; Yi Wu; Yang Yuan; Xiting Yang; Qiman Ran; Xiongyao Gan; Yidong Guo; Xinrong Wang; Yiwen Chu; Kelei Zhao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence about?
## Abstract __P____seud____omon____as aeruginosa__ is a common opportunistic pathogen with growing resistance and presents heightened treatment challenges. Quorum sensing (QS) is a cell-to-cell communication system that contributes to the production of a variety of virulence factors and is also related to biofilm formation of __P. aeruginosa__. Compared to traditional antibiotics which kill bacteria directly, the anti-virulence strategy by targeting QS is a promising strategy for combating pseudomonal infections. In this study, the QS inhibition potential of the compounds derived from the Traditional Chinese Medicines was evaluated by using in silico, in vitro, and in vivo analyses. The results showed that psoralen, a natural furocoumarin compound derived from __Psoralea corylifolia__ L., was capable of simultaneously inhibiting the three main QS regulators, LasR, RhlR, and PqsR of __P__. __aeruginosa.__ Psoralen had no bactericidal activity but could widely inhibit the production of extracellular proteases, pyocyanin, and biofilm, and the cell motilities of the model and clinical __P__. __aeruginosa__ strains. RNA-sequencing and quantitative PCR analyses further demonstrated that
Who reads Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Fulong Wen; Yi Wu; Yang Yuan; Xiting Yang; Qiman Ran; Xiongyao Gan; Yidong Guo; Xinrong Wang; Yiwen Chu; Kelei Zhao
- Publisher
- Springer
- Published
- 2024
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)