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White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia by Yi Zhao; Bronte Ficek; Kimberly Webster; Constantine Frangakis; Brian Caffo; Argye E. Hillis; Andreia Faria; Kyrana Tsapkini is a Medicine article available to read on EtoBox.

What is White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia about?

## Background Transcranial direct current stimulation (tDCS), in conjunction with language therapy, improves language therapy outcomes in primary progressive aphasia (PPA). However, no studies show whether white matter integrity predicts language therapy or tDCS effects in PPA. ## Objective We aimed to determine whether white matter integrity, measured by diffusion tensor imaging (DTI), predicts written naming/spelling language therapy effects (letter accuracy on trained and untrained words) with and without tDCS over the left inferior frontal gyrus (IFG) in PPA. ## Methods Thirty-nine participants with PPA were randomly assigned to tDCS or sham condition, coupled with language therapy for 15 daily sessions. White matter integrity was measured by mean diffusivity (MD) and fractional anisotropy (FA) in DTI scans before therapy. Written naming outcomes were evaluated before, immediately after, 2 weeks, and 2 months posttherapy. To assess tDCS treatment effect, we used a mixed-effects model with treatment evaluation and time interaction. We considered a forward model selection approach to identify brain regions/fasciculi of which white matter integrity can predict improvement in perfo

Who reads White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia?

Author

Yi Zhao; Bronte Ficek; Kimberly Webster; Constantine Frangakis; Brian Caffo; Argye E. Hillis; Andreia Faria; Kyrana Tsapkini

Publisher

SAGE Publications; Sage Science Press (ISSN 0888-4390)

Published

2020

Language

EN

Field

Medicine (Health Sciences)