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Serotonergic connections to the ventral oral pontine reticular nucleus: Implication in paradoxical sleep modulation by Rodrigo-Angulo, Margarita L.; Rodrguez-Veiga, Elisia; Reinoso-Surez, Fernando is a Neuroscience article available to read on EtoBox.

What is Serotonergic connections to the ventral oral pontine reticular nucleus: Implication in paradoxical sleep modulation about?

Cholinergic microstimulation of the ventral part of the oral pontine reticular nucleus (vRPO) in cats generates and maintains paradoxical sleep. The implication of rostral raphe nuclei in modulating the sleep-wakefulness cycle has been based on their serotonergic projections to the pontine structures responsible for the induction of paradoxical sleep. However, serotonergic neurons have also been described in brainstem structures other than the raphe nuclei. The aim of the present work is to trace the origin of the serotonergic afferents to the vRPO and to the locus coeruleus alpha and perilocus coeruleu alpha nuclei, closely related with different paradoxical sleep events. Anterograde and retrograde horseradish peroxidase conjugated with wheat germ agglutinin tracer injections in these nuclei in cats were combined with serotonin antiserum immunohistochemistry. Our results demonstrate that reciprocal connections linking the rostral raphe nuclei to those oral pontine nuclei are scarce. The percentage of double-labeled neurons after injections in the vRPO averaged 18% in rostral raphe nuclei, while a level of 82% was estimated in mesopontine tegmentum structures other than the raphe n

Who reads Serotonergic connections to the ventral oral pontine reticular nucleus: Implication in paradoxical sleep modulation?

Author

Rodrigo-Angulo, Margarita L.; Rodrguez-Veiga, Elisia; Reinoso-Surez, Fernando

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)