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Transmitter-phenotypes of Commissural Interneurons in the Lumbar Spinal Cord of Newborn Mice by Carlos Ernesto Restrepo; Line Lundfald; Gabor Szabó; Ferenc Erdélyi; Hanns Ulrich Zeilhofer; Joel C. Glover; Ole Kiehn is a Neuroscience article available to read on EtoBox.

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## Abstract Commissural interneurons (CINs) are a necessary component of central pattern generators (CPGs) for locomotion because they mediate the coordination of left and right muscle activity. The projection patterns and relative locations of different classes of CINs in the ventromedial part of the rodent lumbar cord have been described (Eide et al. [1999] J Comp Neurol 403:332–345; Stokke et al. [2002] J Comp Neurol 446:349–359; Nissen et al. [2005] J Comp Neurol 483:30–47). However, the distribution and relative prevalence of different CIN neurotransmitter phenotypes in the ventral region of the mammalian spinal cord where the locomotor CPG is localized is unknown. In this study we describe the relative proportions and anatomical locations of putative inhibitory and excitatory CINs in the lumbar spinal cord of newborn mice. To directly visualize potential neurotransmitter phenotypes we combined retrograde labeling of CINs with in situ hybridization against the glycine transporter, GlyT2, or the vesicular glutamate transporter, vGluT2, in wildtype mice and in transgenic mice expressing eGFP driven by the promoters of glutamic acid decarboxylase (GAD) 65, GAD67, or GlyT2. Our st

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Author

Carlos Ernesto Restrepo; Line Lundfald; Gabor Szabó; Ferenc Erdélyi; Hanns Ulrich Zeilhofer; Joel C. Glover; Ole Kiehn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)