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ADC as a predictor of pathologic response to neoadjuvant therapy in esophageal cancer: a systematic review and meta-analysis by Maffazzioli, Leticia; Zilio, Mariana B.; Klamt, Alexandre L.; Duarte, Juliana A.; Mazzini, Guilherme S.; Campos, Vinicius J.; Chedid, Marcio F.; Gurski, Richard R. is a Medicine article available to read on EtoBox.

What is ADC as a predictor of pathologic response to neoadjuvant therapy in esophageal cancer: a systematic review and meta-analysis about?

## Objective: Diffusion-weighted magnetic resonance imaging (dwi) is part of clinical practice. the aim of this study was to evaluate the role of apparent diffusion coefficient (adc) as a predictor of pathologic response to neoadjuvant therapy (ncrt) in patients with esophageal cancer (ec). ## Methods: The medline, embase, and google scholar databases were systematically searched for studies using adc to evaluate response to neoadjuvant therapy in patients with ec. methodological quality of the studies was evaluated with the quadas tool. data from eligible studies were extracted and evaluated by two independent reviewers. meta-analyses were performed comparing mean adc values between responders and non-responders to ncrt in three different scenarios: baseline (bl) absolute values; percent change between intermediate (im) values and bl; and percent change between final follow-up (fu) value and baseline bl. ## Results: Seven studies (n = 158 patients) were included. responders exhibited a statistically significant percent increase in adc during ncrt (mean difference [md] 21.06%, 95%ci = 13.04-29.09; i = 49%; p = 0.12). a similar increase was identified in the complete pathologic resp

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Author
Maffazzioli, Leticia; Zilio, Mariana B.; Klamt, Alexandre L.; Duarte, Juliana A.; Mazzini, Guilherme S.; Campos, Vinicius J.; Chedid, Marcio F.; Gurski, Richard R.
Publisher
Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0938-7994)
Published
2020
Language
EN
Field
Medicine (Health Sciences)

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