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Polymer brushes containing sulfonated sugar repeat units: Synthesis, characterization, and in vitro testing of blood coagulation activation by N. Ayres; D. J. Holt; C. F. Jones; L. E. Corum; D. W. Grainger is a Materials Science article available to read on EtoBox.

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## Abstract A new polymer brush chemistry containing sulfonated carbohydrate repeat units has been synthesized from silicon substrates using ATRP methods and characterized both in bulk and using surface analysis. The polymer brush was designed to act as a mimic for the naturally occurring sulfonated glycosaminoglycan, heparin, commonly used for modifying blood‐contacting surfaces both __in vitro__ and __in vivo__. Surface analysis showed conversion of brush saccharide precursor chemistry to the desired sulfonated polymer product. The sulfonated polymer brush surface was further analyzed using three conventional __in vitro__ tests for blood compatibility—plasma recalcification times, complement activation, and thrombin generation. The sulfonated polymer brush films on silicon oxide wafers exhibited better assay performance in these blood component assays than the unsulfonated sugar functionalized polymer brush in all tests performed. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7713–7724, 2008

Who reads Polymer brushes containing sulfonated sugar repeat units: Synthesis, characterization, and in vitro testing of blood coagulation activation?

Author

N. Ayres; D. J. Holt; C. F. Jones; L. E. Corum; D. W. Grainger

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-624X)

Published

2008

Language

EN

Field

Materials Science (Physical Sciences)