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Safety and Efficacy of Autologous Intra-articular Platelet Lysates in Early and Intermediate Knee Osteoarthrosis in Humans: A Prospective Open-Label Study by Jihad Al-Ajlouni; Abdalla Awidi; Osama Samara; Mahasan Al-Najar; Emad Tarwanah; Mohannad Saleh; Mohammad Awidi; Freh Abu Hassan; Mohammad Samih; Abdulbari Bener; Manar Dweik is a Medicine article available to read on EtoBox.

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## Objective: To explore the safety and benefit from intra-articular autologous platelet lysate (pl) injection in early and intermediate knee osteoarthritis. ## Design: Open-label prospective study. ## Setting: Laboratory. ## Patients: Adult patients, aged 35 to 70 years, with a history of chronic pain or swelling on one or both knees and imaging findings (radiograph or magnetic resonance imaging) of degenerative changes in the joint of grade i or ii on the kellgren scale were included. ## Interventions: Autologous pl was given in the knee joint by percutaneous intra-articular route every 3 weeks for a total of 3 injections. ## Main outcome measures: Response was evaluated by nonnormalized knee osteoarthritis and disability outcome score (koos). ## Results: There was a significant improvement in the 5 aspects evaluated at weeks 32 and 52 compared with baseline. symptoms score significantly improved at weeks 32 and 52 from a mean of 11.1 at baseline to 9.0 (p < 0.0001) and 8.7 (p < 0.0001). stiffness score significantly improved at weeks 32 and 52 from 2.2 at baseline to 1.7 (p < 0.022) and 1.6 (p < 0.016). pain score improved at 32 weeks and at 52 weeks from a baseline of 14.2 to 9

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Author

Jihad Al-Ajlouni; Abdalla Awidi; Osama Samara; Mahasan Al-Najar; Emad Tarwanah; Mohannad Saleh; Mohammad Awidi; Freh Abu Hassan; Mohammad Samih; Abdulbari Bener; Manar Dweik

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2014

Language

EN

Field

Medicine (Health Sciences)