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Can I read Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons on EtoBox?
Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons by Liang-Yo Yang; Arthur P. Arnold is a Neuroscience article available to read on EtoBox.
What is Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons about?
In androgen-sensitive motoneurons of the spinal nucleus of the bulbocavernosus (SNB), we investigated the interaction of BDNF (brain-derived neurotrophic factor) and testosterone to understand whether each factor gates the ability of the other to regulate androgen receptor expression and soma size, and whether each factor requires the presence of the other for its action. We axotomized SNB motoneurons and applied BDNF or PBS (phosphate-buffered saline) to the cut ends of the axons in rats that were castrated and treated with either testosterone or placebo. Control groups were either not castrated or not axotomized, or had intact SNB axons and were castrated and treated with testosterone or placebo. We found that testosterone determined the expression of nuclear androgen receptor, and this effect was enhanced by both BDNF and contact with the target muscles. The effect of BDNF on androgen receptor expression was seen only when testosterone was present. In the regulation of soma size, BDNF dominated. The application of BDNF completely compensated for the loss of testosterone in castrated males so that the testosterone effect on soma size was seen only in intact SNB motoneurons and in
Who reads Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Liang-Yo Yang; Arthur P. Arnold
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3034)
- Published
- 2000
- Language
- EN
- Field
- Neuroscience (Life Sciences)