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Nephroprotective effect of ethanolic extract of Azima tetracantha root in glycerol induced acute renal failure in Wistar albino rats by Venugopala Rao Konda; Ruckmani Arunachalam; Madhavi Eerike; Ramesh Rao K; Arun Kumar Radhakrishnan; Lakshmipathy Prabhu Raghuraman; Vinayak Meti; Sobita Devi is a Medicine article available to read on EtoBox.
What is Nephroprotective effect of ethanolic extract of Azima tetracantha root in glycerol induced acute renal failure in Wistar albino rats about?
The gravity of the impact of renal failure on human health is well known and as there is no specific pharmacotherapy for renal failure, the current study was undertaken to evaluate the effect of root extract of __Azima tetracantha__, an ancient medicinal plant used in Siddha and Ayurvedhic systems of medicine. The experiment was done in glycerol-induced acute renal failure in Wistar albino rats. Thirty rats were divided into five groups. Group 1 was given normal saline (10 ml/kg) per oral, group 2 with single dose of hypertonic glycerol (8 ml/kg) by intramuscular injection into the hind limbs, group 3 with glycerol and ethanolic extract of __A. tetracantha__ root (ATR) 250 mg/kg, group 4, glycerol and ATR 500 mg/kg and group 5, 500 mg/kg ATR. Extract was given orally 60 min prior to glycerol injection. 24 h urine output, serum creatinine, blood urea nitrogen, total proteins and albumin were measured for all the groups. Kidneys were examined for histopathological changes. The antioxidant activity of the extract was tested __in vitro__ and __in vivo__. Rats treated with ATR showed significant improvement in biochemical parameters and histopathological changes compared to glycerol tre
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- Author
- Venugopala Rao Konda; Ruckmani Arunachalam; Madhavi Eerike; Ramesh Rao K; Arun Kumar Radhakrishnan; Lakshmipathy Prabhu Raghuraman; Vinayak Meti; Sobita Devi
- Publisher
- Elsevier BV
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)