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Optimization and Characterization of Controlled Release Multi-particulate Beads Formulated with a Customized Cellulose Acetate Butyrate Dispersion by Siva Vaithiyalingam; Mansoor A Khan is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The objectives of the present investigation were: (1) to model the effect of process and formulation variables viz., coating weight gain, duration of curing, and plasticizer concentration on in-vitro release profile of verapamil HCl from multi-particulate beads formulated with a novel aqueous-based pseudolatex dispersion; (2) to optimize the formulation by response surface methodology (RSM) and artificial neural network (ANN); and (3) to characterize the optimized product by thermal and X-ray analyses. Inert beads (Nupareil ® ) were loaded with verapamil HCl and subsequently coated with a custom designed aqueous-based pseudolatex dispersion of cellulose acetate butyrate (CAB). Experiments were designed and data was collected according to a three factor, three level face centered central composite design. Data was analyzed for modeling and optimizing the release profile using both RSM and ANN. Model fitted the data and explained 90% of variability in response in the case of RSM and at least 70% in the case of ANN. Release profile was optimized for a zero-order model. Optimized formulations were prepared according to the factor combinations dictated by RSM and ANN. In each case, the

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Author

Siva Vaithiyalingam; Mansoor A Khan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2002

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)