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Transcription Factor Egr-1 Activates Collagen Expression in Immortalized Fibroblasts or Fibrosarcoma Cells by D. Alexander; M. Judex; R. Meyringer; M. Weis-Klemm; S. Gay; U. Müller-Ladner; W.K. Aicher is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Ritchlin et al., 1994) that contribute to the destruction of articular cartilage, finally resulting in ankylosis of affected joints. Previous studies revealed that synovial fibroblasts from RA patients express elevated levels of early growth response factor-1 (Egr-1) (Aicher et al., 1994). Members of the early growth response gene family are implicated in the activation of cells including proliferation, differentiation and alteration in gene expression (Sukhatme et al., 1988;Herschman et al., 1991;Dinkel et al., 1998). Egr-1 is rapidly and transiently induced by a variety of growth factors, cytokines, hypoxia and stress (Gashler et al., 1995). The protein contains a DNA-binding domain consisting of three zinc fingers that specifically recognize a GC-rich consensus region (GCG(T/G)GGGCG). When bound to DNA, Egr-1 influences the transcription of various genes through mechanisms dependent on both coactivators and corepressors. It has been shown that Egr-1 may play a role in the development of thymocytes (Myazaki et al., 1997). We demonstrated also that Egr-1 accelerates the maturation of B-cells (Dinkel et al., 1998). The expression of growth factors such as PDGF-A chain (Khachigia

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Author

D. Alexander; M. Judex; R. Meyringer; M. Weis-Klemm; S. Gay; U. Müller-Ladner; W.K. Aicher

Publisher

Walter de Gruyter GmbH

Published

2002

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)