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Racial/ethnic Differences in Treatment Efficacy and Safety for Moderate-to-severe Plaque Psoriasis: a Systematic Review by Jessica E. Ferguson; Edward W. Seger; Jacob White; Amy McMichael is a Medicine article available to read on EtoBox.

What is Racial/ethnic Differences in Treatment Efficacy and Safety for Moderate-to-severe Plaque Psoriasis: a Systematic Review about?

Biologic medications have revolutionized treatment of psoriasis; however, there remains uncertainty in which medications should be used to maximize efficacy based on race/ethnicity. The purpose was to determine if efficacy of biological medications differs based on race/ethnicity. A systematic review identified all clinical trials focused on biologic treatment outcomes from inception of database until March 5th, 2021. Included studies provided data on racial/ethnic differences in biologic skin clearance efficacy using the Psoriasis Area and Severity Index (PASI) and "clear/almost clear" scores. There were 1220 studies identified, and 24 included in the review. The races/ethnicities included were Asian (n = 2740), White (n = 9745), Black (n = 138), and Latino (n = 728). Ixekizumab provided the highest "clear/almost clear" score (90.7%, 89.4%) and PASI 75 (98.8%, 96.6%) for Asian and Latino patients, respectively. Guselkumab had the highest "clear/almost clear" score for White (86.8%) patients, while Black patients had highest "clear/almost clear" (75.0%) and PASI 75 (91.7%) scores to brodalumab. Limitations included lack of studies reporting outcome data based on race/ethnicity and

Who reads Racial/ethnic Differences in Treatment Efficacy and Safety for Moderate-to-severe Plaque Psoriasis: a Systematic Review?

Author

Jessica E. Ferguson; Edward W. Seger; Jacob White; Amy McMichael

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)