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Immunogenicity and Reactogenicity of a Highly Purified Vaccine Against Tick-borne Encephalitis by Christian Kunz; Franz X. Heinz; Hanns Hofmann is a Medicine article available to read on EtoBox.

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## Abstract Immunogenicity and reactogenicity of a vaccine containing inactivated tick‐borne encephalitis vims prepared by continuous flow zonal ultracentrifugation were compared with those of a previously used, less purified vaccine. Antibody response as measured by hemagglutination inhibition (HI) and enzyme‐linked immunosorbent assay (ELISA) was 93% after two vaccinations and 100% after a third dose. The zonally purified vaccine impressively reduced the incidence of side reactions. Pyrexia (> 37.3°C) was recorded in only 4–10% of the vaccinees almost exclusively after first vaccinations compared to 17–68% with the old type of vaccine. When these results are evaluated according to criteria commonly used in the United States (ie, pyrexia> 100°F = 37.8°C), almost no fever would be recorded. The frequency of systemic side reactions was even lower (statistically significant) after second and third vaccinations. This highly purified vaccine therefore represents an effective and well‐tolerated means for the immunoprophylaxis of TBE.

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Author

Christian Kunz; Franz X. Heinz; Hanns Hofmann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

1980

Language

EN

Field

Medicine (Health Sciences)