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Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies by Maria C. Magnus; Abigail Fraser; Siri E. Håberg; Kristiina Rönö; Liv Bente Romundstad; Christina Bergh; Anne Lærke Spangmose; Anja Pinborg; Mika Gissler; Ulla-Britt Wennerholm; Bjørn Olav Åsvold; Deborah A. Lawlor; Signe Opdahl is a Medicine article available to read on EtoBox.

What is Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies about?

## Importance The use of assisted reproductive technologies (ARTs) is steadily increasing worldwide. The outcomes associated with treatment for an individual’s long-term health, including risk of cardiovascular disease (CVD), remain largely unknown, due to the small number of studies and their limited follow-up time. ## Objective To study whether the risk of CVD is increased among individuals who have given birth after ART compared with those who have given birth without ART. ## Design, Setting, and Participants A registry-based cohort study was conducted using nationwide data from Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015), and Sweden (1985-2015). Data analysis was conducted from January to August 2022. A total of 2 496 441 individuals with a registered delivery in the national birth registries during the study period were included, and 97 474 (4%) of these gave birth after ART. ## Exposures Data on ART conception were available from ART quality registries and/or medical birth registries. ## Main Outcomes and Measures Information on CVD was available from patient and cause of death registries. The risk of CVD was estimated with Cox proportional hazards regression

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Author

Maria C. Magnus; Abigail Fraser; Siri E. Håberg; Kristiina Rönö; Liv Bente Romundstad; Christina Bergh; Anne Lærke Spangmose; Anja Pinborg; Mika Gissler; Ulla-Britt Wennerholm; Bjørn Olav Åsvold; Deborah A. Lawlor; Signe Opdahl

Publisher

American Medical Association (AMA)

Published

2023

Language

EN

Field

Medicine (Health Sciences)