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Differentiation of highly prevalent IS6110 single-copy strains of Mycobacterium tuberculosis from a rural community in South India with an ongoing DOTS programme by Sulochana D. Das; Sujatha Narayanan; Lalitha Hari; S.L. Hoti; R.K. Thangathurai; Niruparani Charles; K. Jaggarajamma; P.R. Narayanan is a Medicine article available to read on EtoBox.
What is Differentiation of highly prevalent IS6110 single-copy strains of Mycobacterium tuberculosis from a rural community in South India with an ongoing DOTS programme about?
We have prospectively analysed the DNA fingerprinting of Mycobacterium tuberculosis strains in a rural community from high prevalence area in South India with an ongoing DOTS programme. Strains from 451 culture-positive cases, diagnosed during July 1999-December 2000, were fingerprinted initially by both IS6110 and DR probes followed by polymorphic GC-rich repeat sequences (PGRS) typing only on lowcopy strains. The results were correlated with selected epidemiological and clinical data. Forty one percent of strains showed single copy of IS6110, which further got differentiated into 62 DR and 27 PGRS patterns. One predominant DR pattern (5B/2) was found in 20% of the lowcopy strains and was also involved in clusters. In all, 183 patients out of 451 (40%) were clustered in total 44 clusters when analysed by IS6110 and DR probes. With additional PGRS typing, the number of patients clustered was further reduced to 106 (23%). More number of patients (131) were clustered in IS6110 single-copy group. The maximum number of clusters was found with two or three patients. Only a small percentage (16%) of the patients reported direct epidemiological links while remaining patients might have ha
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- Author
- Sulochana D. Das; Sujatha Narayanan; Lalitha Hari; S.L. Hoti; R.K. Thangathurai; Niruparani Charles; K. Jaggarajamma; P.R. Narayanan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)