Opening book details…
Can I read 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog on EtoBox?
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog by Subas M. Sakya; Kristin M. Lundy DeMello; Martha L. Minich; Bryson Rast; Andrei Shavnya; Robert J. Rafka; David A. Koss; Hengmiao Cheng; Jin Li; Burton H. Jaynes; Carl B. Ziegler; Donald W. Mann; Carol F. Petras; Scott B. Seibel; Annette M. Silvia; David M. George; Lisa A. Lund; Suzanne St. Denis; Anne Hickman; Michelle L. Haven; Michael P. Lynch is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog about?
Structure-activity relationship (SAR) studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-yl]-5-methanesulfonyl (SO(2)Me)/sulfamoyl (SO(2)NH(2))-pyridine derivatives for canine COX enzymes are described. The studies led to the identification of 2e as lead with potent in vitro activity, selectivity, and in vivo activity in dogs and cats.
Who reads 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Subas M. Sakya; Kristin M. Lundy DeMello; Martha L. Minich; Bryson Rast; Andrei Shavnya; Robert J. Rafka; David A. Koss; Hengmiao Cheng; Jin Li; Burton H. Jaynes; Carl B. Ziegler; Donald W. Mann; Carol F. Petras; Scott B. Seibel; Annette M. Silvia; David M. George; Lisa A. Lund; Suzanne St. Denis; Anne Hickman; Michelle L. Haven; Michael P. Lynch
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)