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Heavy Metals Induce TDP-43 in ALS by Oalsahafi is a document available to read on EtoBox.

What is Heavy Metals Induce TDP-43 in ALS about?

The document discusses how certain heavy metals like lead, tin, and mercury can induce ALS-linked TDP-43 pathology. It shows that these heavy metals cause changes in TDP-43 localization and accumulation in neurons, as well as increased TDP-43 aggregation. The study also demonstrates that heavy metals can affect TDP-43 splicing activity and promote its liquid-liquid phase separation.

Author

Oalsahafi

Language

EN