Can I read Rapid Determination of Trace Elements in Serum of Hepatocellular Carcinoma Patients by Inductively Coupled Plasma Tandem Mass Spectrometry on EtoBox?

Rapid Determination of Trace Elements in Serum of Hepatocellular Carcinoma Patients by Inductively Coupled Plasma Tandem Mass Spectrometry by Liang Fu; Hualin Xie; Jianhua Huang; Lin Chen is a Chemistry article available to read on EtoBox.

What is Rapid Determination of Trace Elements in Serum of Hepatocellular Carcinoma Patients by Inductively Coupled Plasma Tandem Mass Spectrometry about?

The occurrence and development of hepatocellular carcinoma (HCC) is related to the level of trace elements. The mechanism of changes in trace element concentration and the identification of HCC risks associated with them are not clear. Therefore, an accurate and reliable approach for quantification of the level of trace elements in the serum of liver cancer patients is of great significance. In this study, we proposed a novel strategy for accurate determination of trace elements such as Mn, Fe, Ni, Cu, Zn, and Se in the serum of HCC patients based on inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). In the MS/MS mode, NO was used as the reaction gas, and an octopole reaction system (ORS) was employed to provide interference-free conditions and a sufficiently low limit of detection (LOD) for the determination of analytical elements. The internal standard elements with similar masses and similar mass spectrometry behavior were selected to correct the matrix effect. The LODs of Mn, Fe, Ni, Cu, Zn, and Se were as low as 0.013, 0.25, 0.010, 0.020, 0.17, and 0.008 μg L, respectively. Bovine serum (SRM 1598a) was adopted as the standard reference material to evaluate the ac

Who reads Rapid Determination of Trace Elements in Serum of Hepatocellular Carcinoma Patients by Inductively Coupled Plasma Tandem Mass Spectrometry?

Author

Liang Fu; Hualin Xie; Jianhua Huang; Lin Chen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)

Published

2020

Language

EN

Field

Chemistry (Physical Sciences)