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Oxidative Modification of Low-density Lipoproteins and the Outcome of Renal Allografts at 11/2 Years by Bosmans, Jean-Louis; Holvoet, Paul; Dauwe, Simonne E.H.; Ysebaert, Dirk K.; Chapelle, Thierry; Jurgens, Angelika; Kovacic, Vera; Van Marck, Eric A.; De Broe, Marc E.; Verpooten, Gert A. is a Medicine article available to read on EtoBox.

What is Oxidative Modification of Low-density Lipoproteins and the Outcome of Renal Allografts at 11/2 Years about?

## Background: Previous studies reported a significant association between hyperlipidemia of the recipient and chronic allograft nephropathy (can). however, the nature and the pathogenic mechanism of circulating lipid abnormalities in can remain unclear. ## Methods: In a prospective study of 50 consecutive adult recipients of a cadaveric renal allograft, we investigated the impact of lipid abnormalities on the outcome of the graft at 1 1/2 years. besides morphometric analysis of implantation and protocol biopsies, clinical and biochemical variables were studied at three-month intervals. plasma concentrations of oxidized low-density lipoprotein (oxldl) were determined by means of enzyme-linked immunosorbent assay. immunohistochemical staining for oxldl and macrophages was performed on paired renal biopsies. study end points were the fractional interstitial volume and the 24-hour creatinine clearance at 11/2 years. ## Results: High-density lipoprotein (hdl) cholesterol of the recipient < or =47 mg/dl was a risk factor for the functional (rr = 1.56; 95% ci, 0.978 to 2.497) and the morphological (rr = 2.75; 95% ci, 1.075 to 7.037) outcome of the graft, mainly in patients without acute

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Author

Bosmans, Jean-Louis; Holvoet, Paul; Dauwe, Simonne E.H.; Ysebaert, Dirk K.; Chapelle, Thierry; Jurgens, Angelika; Kovacic, Vera; Van Marck, Eric A.; De Broe, Marc E.; Verpooten, Gert A.

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)

Published

2001

Language

EN

Field

Medicine (Health Sciences)