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The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments by Wenyan Wan; Hui Dong; De-Hua Lai; Jiong Yang; Kai He; Xiaoyan Tang; Qun Liu; Geoff Hide; Xing-Quan Zhu; L. David Sibley; Zhao-Rong Lun; Shaojun Long is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments about?
## Abstract Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a dense neck, termed the micropore, on the surface of intracellular parasites. However, the function of this structure remains unknown. Here we validate the micropore as an essential organelle for endocytosis of nutrients from the host cell cytosol and Golgi in the model apicomplexan Toxoplasma gondii. Detailed analyses demonstrated that Kelch13 is localized at the dense neck of the organelle and functions as a protein hub at the micropore for endocytic uptake. Intriguingly, maximal activity of the micropore requires the ceramide de novo synthesis pathway in the parasite. Thus, this study provides insights into the machinery underlying acquisition of host cell-derived nutrients by apicomplexan parasites that are otherwise sequestered from host cell compartments.
Who reads The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wenyan Wan; Hui Dong; De-Hua Lai; Jiong Yang; Kai He; Xiaoyan Tang; Qun Liu; Geoff Hide; Xing-Quan Zhu; L. David Sibley; Zhao-Rong Lun; Shaojun Long
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)