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This study investigates the role of aerobic glycolysis in T cell activation and effector function, revealing that while oxidative phosphorylation (OXPHOS) is necessary for T cell activation and proliferation, aerobic glycolysis is specifically required for optimal production of effector cytokines like IFN-γ. The research demonstrates that the glycolysis enzyme GAPDH regulates the translation of IFN-γ mRNA, indicating that aerobic glycolysis serves as a metabolic signaling mechanism essential for T cell func
- Author
- ThiKem Nguyen
- Language
- EN