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Can I read Molecular Markers of Prognosis in Astrocytic Tumors on EtoBox?
Molecular Markers of Prognosis in Astrocytic Tumors by Ahmed Rasheed; James E. Herndon; Timothy T. Stenzel; Jacqueline G. M. Raetz; Jason Kendelhardt; Henry S. Friedman; Allan H. Friedman; Darell D. Bigner; Sandra H. Bigner; Roger E. McLendon is a Medicine article available to read on EtoBox.
What is Molecular Markers of Prognosis in Astrocytic Tumors about?
## Abstract ## BACKGROUND Astrocytoma is a primary brain tumor that affects 20,000 Americans each year. To date, only age and histologic grade stand out as independent predictors of survival. There is now increased interest in the use of molecular markers as objective standards against which to establish diagnosis and grade. ## METHODS The study evaluated human glioma tumor suppressor genes and associated loci in fresh snap‐frozen gliomas from 63 males and 37 females, with a median age of 42 years, including 19 low‐grade astrocytomas. The tumor samples were selected so that about equal numbers of glioblastomas from younger and older patients were represented in the series. Methods for suppressor gene and genetic loci evaluation included loss of heterozygosity (LOH) analysis, multiplex polymerase chain reaction analysis, and gene sequencing. ## RESULTS Low‐grade astrocytomas had the least number of molecular abnormalities. LOH on 9p and/or CDKN2A deletion occurred more often in glioblastomas (__P__ < 0.001), LOH on 17p/TP53 mutations occurred more frequently in anaplastic astrocytomas (AAs; __P__ = 0.112), and LOH on 10q/PTEN mutation frequency was similar in glioblastomas and AAs (
Who reads Molecular Markers of Prognosis in Astrocytic Tumors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ahmed Rasheed; James E. Herndon; Timothy T. Stenzel; Jacqueline G. M. Raetz; Jason Kendelhardt; Henry S. Friedman; Allan H. Friedman; Darell D. Bigner; Sandra H. Bigner; Roger E. McLendon
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)