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Oral Squamous Cell Carcinoma Cells Induce Osteoclast Differentiation by Suppression of Osteoprotegerin Expression in Osteoblasts by Takeyuki Tada; Eijiro Jimi; Masato Okamoto; Satoru Ozeki; Koji Okabe is a Medicine article available to read on EtoBox.

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## Abstract The invasion of oral squamous cell carcinoma (SCC) cells into the mandibular bone is a common clinical problem. It has been reported that BHY cells, a human oral SCC cell line, are capable of invading mandibular bone of nude mice. These results led us to examine possible mechanisms of osteoclastogenesis induced by BHY cells using __in vitro__ culture systems. When BHY cells were cocultured with mouse bone marrow cells (BMCs), only few osteoclasts were formed, even though BHY cells express the receptor activator of NF‐κB ligand (RANKL). However, adding BHY cells to a coculture of mouse primary osteoblasts (POBs) and BMCs markedly induced osteoclastogenesis in the absence of osteotropic factors. Furthermore, another oral SCC cell line, HSC‐2, which does not express RANKL, also induced osteoclastogenesis in our cocultures. These effects were significantly, but not completely, inhibited by adding osteoprotegerin (OPG). In addition, we also found that TNFα released from these cells partially contributes to osteoclastogenesis __via__ a RANKL‐independent mechanism. Adding BHY or HSC‐2 cells suppressed mouse OPG mRNA expression and protein production by POBs in cocultures of PO

Who reads Oral Squamous Cell Carcinoma Cells Induce Osteoclast Differentiation by Suppression of Osteoprotegerin Expression in Osteoblasts?

Author

Takeyuki Tada; Eijiro Jimi; Masato Okamoto; Satoru Ozeki; Koji Okabe

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)