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The authors created a 3D biomimetic scaffold incorporating a method for delivering PTH directly to a bone defect site. The PTH delivery system is designed to release the hormone in either a pulsatile or continuous manner over 21 days using biodegradable materials. Local pulsatile PTH delivery from this scaffold regenerates bone defects and achieves higher quality bone than systemic PTH injections via enhanced bone remodeling.

Author

20210901025

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EN