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The Streptococcus milleri group—An unrecognized cause of disease in cystic fibrosis: A case series and literature review by Michael D. Parkins; Christopher D. Sibley; Michael G. Surette; Harvey R. Rabin is a Medicine article available to read on EtoBox.

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## Abstract The “__Streptococcus milleri__” group (SMG) is increasingly recognized for their role in pyogenic infections including empyema and solid organ abscesses. However, SMG disease has rarely been identified in cystic fibrosis (CF). Inherent difficulties in both growing the organisms and distinguishing SMG from less virulent oropharyngeal viridans streptococci may have led to a decreased recognition of this as a CF pathogen. We report on six cases of SMG‐related infection over a 4‐year time‐frame occurring within an adult CF clinic in Canada, and a further four cases identified through a literature review. SMG manifested disease as bronchopulmonary exacerbations in 7 of 10 patients, and 4 of 10 patients had extra‐pulmonary dissemination of SMG infection. Noticeably, pulmonary exacerbations were frequently associated with atypically malodorous sputum. Furthermore, patients clinically responded to anti‐microbial therapies with no anti‐Pseudomonal activity. There was a consistent correlation of SMG disease and co‐colonization with __P. aeruginosa__ leading to speculation of polymicrobial interactions resulting in enhanced virulence. SMG deserves considerable attention as a poten

Who reads The Streptococcus milleri group—An unrecognized cause of disease in cystic fibrosis: A case series and literature review?

Author

Michael D. Parkins; Christopher D. Sibley; Michael G. Surette; Harvey R. Rabin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

2008

Language

EN

Field

Medicine (Health Sciences)