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Development of a Three-dimensionally Printed Scaffold Grafted with Bone Forming Peptide-1 for Enhanced Bone Regeneration with in Vitro and in Vivo Evaluations by Sang Jin Lee; Jong-Eun Won; Changhak Han; Xiang Yun Yin; Hyung Keun Kim; Haram Nah; Il Keun Kwon; Byoung-Hyun Min; Chul-Ho Kim; Yoo Seob Shin; Su A Park is a Chemistry article available to read on EtoBox.
What is Development of a Three-dimensionally Printed Scaffold Grafted with Bone Forming Peptide-1 for Enhanced Bone Regeneration with in Vitro and in Vivo Evaluations about?
Defects in bone are some of the most difficult injuries to treat. Biomimetic scaffolds represent a promising approach for successful bone tissue regeneration. In this study, a three-dimensional (3D) scaffold with osteo-inductive functionality was designed and assayed both in-vitro and in-vivo. Bone formation peptide-1 (BFP1), an osteo-promoting specific peptide, was covalently bound to a 3D printed polycaprolactone (PCL) scaffold using polydopamine (DOPA). The amount of BFP1 immobilized on the surface was found to increase depending on the BFP1 concentration of the loading solution. To observe the biological effects of the 3D scaffolds, human tonsil-derived mesenchymal stem cells (hTMSCs) were isolated. The cells were cultured on the scaffolds and observed to rapidly differentiate into osteoblast-like cells with osteo-promoting capabilities. The scaffolds were implanted in a rabbit calvarial defect model for 8 weeks and successfully stimulated both vessel and bone regeneration. Osteo-promoting 3D scaffolds may provide a safer and more efficient approach for bone repair and remodelling in regenerative medicine.
Who reads Development of a Three-dimensionally Printed Scaffold Grafted with Bone Forming Peptide-1 for Enhanced Bone Regeneration with in Vitro and in Vivo Evaluations?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Sang Jin Lee; Jong-Eun Won; Changhak Han; Xiang Yun Yin; Hyung Keun Kim; Haram Nah; Il Keun Kwon; Byoung-Hyun Min; Chul-Ho Kim; Yoo Seob Shin; Su A Park
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0021-9797)
- Published
- 2019
- Language
- EN
- Field
- Chemistry (Physical Sciences)