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Time to Metabolic Atrophy After Permanent Prostate Seed Implantation Based on Magnetic Resonance Spectroscopic Imaging by Barby Pickett; Randall K. Ten Haken; John Kurhanewicz; Aliya Qayyum; Katsuto Shinohara; Beverly Fein; Mack Roach III is a Medicine article available to read on EtoBox.

What is Time to Metabolic Atrophy After Permanent Prostate Seed Implantation Based on Magnetic Resonance Spectroscopic Imaging about?

Purpose: To characterize the time to metabolic atrophy (TMA) after permanent prostate implantation (PPI) using combined MRI and magnetic resonance spectroscopic imaging (MRSI) compared with the time to prostate-specific antigen (PSA) nadir. Methods and Materials: This study was based on a posttreatment analysis comparing the MRI/MRSI findings with the PSA levels of 65 patients treated with PPI alone or combined with external beam radiotherapy and/or HT. The fraction of interpretable voxels demonstrating metabolic atrophy was used to compare the TMA with the time to PSA nadir. Results: The fraction of patients with metabolic atrophy in >95% of usable voxels after PPI increased from ϳ46% to 100% at 6 and 48 months, respectively. The mean time for PSA nadir vs. TMA was 42.5 vs. 28.9 months (PPI), 32.8 vs. 25.6 months (external beam radiotherapy ؉ PPI), and 25.3 vs. 28.0 months (external beam radiotherapy ؉ hormonal therapy ؉ PPI). Conclusion: Magnetic resonance spectroscopic imaging may provide an early tool for evaluating the treatment response for patients treated with PPI. If supported by longer follow-up, TMA may be a useful adjunct to PSA measurement for assessing local control a

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Author

Barby Pickett; Randall K. Ten Haken; John Kurhanewicz; Aliya Qayyum; Katsuto Shinohara; Beverly Fein; Mack Roach III

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2004

Language

EN

Field

Medicine (Health Sciences)