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Determination of Nefazodone and Its Pharmacologically Active Metabolites in Human Blood Plasma and Breast Milk by High-performance Liquid Chromatography by Seetal Dodd; Anne Buist; Graham D Burrows; Kay P Maguire; Trevor R Norman is a Chemistry article available to read on EtoBox.

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A method is described for the determination of nefazodone and its active metabolites hydroxynefazodone, the dione BMS-180492 and m-chlorophenylpiperazine in blood plasma and expressed human milk based on reversed-phase highperformance liquid chromatography. Measurements were performed on drug-free plasma and expressed human milk spiked with nefazodone and metabolites to prepare and validate standard curves and specimens collected from nursing mothers. Parent drug and metabolites were separated from the biological matrices by solid-phase extraction using CERTIFY columns. Chromatographic separation was achieved with a C column and compounds were detected by their absorbance at 205 nm. ## 18 Trazodone was used as an internal standard. The assay was validated for each analyte in the concentration range 200 to 1200 ng / ml.

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Author

Seetal Dodd; Anne Buist; Graham D Burrows; Kay P Maguire; Trevor R Norman

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1999

Language

EN

Field

Chemistry (Physical Sciences)