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The Mouse Alpha-globin Cluster: a Paradigm for Studying Genome Regulation and Organization by A Marieke Oudelaar; Robert A Beagrie; Mira T Kassouf; Douglas R Higgs is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Mouse Alpha-globin Cluster: a Paradigm for Studying Genome Regulation and Organization about?

The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the α-globin genes in well-defined cell populations has enabled investigation of the structural and functional roles of its enhancers, promoters and boundary elements. Recent studies of gene regulatory processes involving these elements at the mouse α-globin cluster have brought new insights into the general principles underlying the three-dimensional structure of the genome and its relationship to gene expression throughout time.

Who reads The Mouse Alpha-globin Cluster: a Paradigm for Studying Genome Regulation and Organization?

Author

A Marieke Oudelaar; Robert A Beagrie; Mira T Kassouf; Douglas R Higgs

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0959-437X)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)