Opening book details…
Can I read Immunotactoid Glomerulopathy Is a Rare Entity with Monoclonal and Polyclonal Variants on EtoBox?
Immunotactoid Glomerulopathy Is a Rare Entity with Monoclonal and Polyclonal Variants by Samih H. Nasr; Satoru S. Kudose; Samar M. Said; Dominick Santoriello; Mary E. Fidler; Sean R. Williamson; Sibel Erdogan Damgard; Sanjeev Sethi; Nelson Leung; Vivette D. D’Agati; Glen S. Markowitz is a Medicine article available to read on EtoBox.
What is Immunotactoid Glomerulopathy Is a Rare Entity with Monoclonal and Polyclonal Variants about?
Immunotactoid glomerulopathy (ITG) is a rare form of glomerulonephritis for which our understanding is limited to case reports and small case series. Herein we describe the clinical, pathologic, and outcome characteristics of 73 patients with ITG who typically presented with proteinuria, hematuria, and renal insufficiency. Hematologic disorders were present in 66% of patients, including lymphoma in 41% (mainly chronic lymphocytic leukemia/small lymphocytic lymphoma), monoclonal gammopathy in 20%, and multiple myeloma in 6%. Light microscopy revealed endocapillary proliferative (35%), membranoproliferative (29%) and membranous (29%) patterns of glomerular involvement. Electron microscopy revealed characteristic microtubular deposits with a diameter of 14-60 nm, hollow cores, frequent parallel alignment, and a predominant distribution outside of the lamina densa of the glomerular basement membrane. Importantly, immunofluorescence revealed IgG-dominant staining which was light chain and IgG subclass restricted in 67% of cases, indicating monoclonal composition. This finding was used to distinguish monoclonal and polyclonal variants of ITG. As compared to polyclonal, monoclonal ITG had
Who reads Immunotactoid Glomerulopathy Is a Rare Entity with Monoclonal and Polyclonal Variants?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Samih H. Nasr; Satoru S. Kudose; Samar M. Said; Dominick Santoriello; Mary E. Fidler; Sean R. Williamson; Sibel Erdogan Damgard; Sanjeev Sethi; Nelson Leung; Vivette D. D’Agati; Glen S. Markowitz
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)