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Can I read Origin of translational control by eIF2α phosphorylation: insights from genome-wide translational profiling studies in fission yeast on EtoBox?
Origin of translational control by eIF2α phosphorylation: insights from genome-wide translational profiling studies in fission yeast by Katsura Asano is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Origin of translational control by eIF2α phosphorylation: insights from genome-wide translational profiling studies in fission yeast about?
During amino acid limitation, the protein kinase Gcn2 phosphorylates the α subunit of eIF2, thereby regulating mRNA translation. In yeast Saccharomyces cerevisiae and mammals, eIF2α phosphorylation regulates translation of related transcription factors Gcn4 and Atf4 through upstream open reading frames (uORFs) to activate transcription genome wide. However, mammals encode three more eIF2α kinases activated by distinct stimuli. Did the translational control system involving eIF2α phosphorylation evolve from so simple (as found in yeast S. cerevisiae) to complex (as found in humans)? Recent genomewide translational profiling studies of amino acid starvation response in the fission yeast Schizosaccharomyces pombe provide an unexpected answer to this question.
Who reads Origin of translational control by eIF2α phosphorylation: insights from genome-wide translational profiling studies in fission yeast?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Katsura Asano
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)