Can I read Graft Intolerance Syndrome in Children with Failed Kidney Allografts--clinical Presentation, Treatment Options and Outcome on EtoBox?

Graft Intolerance Syndrome in Children with Failed Kidney Allografts--clinical Presentation, Treatment Options and Outcome by I. Krause; R. Cleper; A. Belenky; E. Atar; N. Bar-Nathan; M. Davidovits is a Medicine article available to read on EtoBox.

What is Graft Intolerance Syndrome in Children with Failed Kidney Allografts--clinical Presentation, Treatment Options and Outcome about?

## Background: Failed renal allografts left in situ may cause inflammation presenting as graft intolerance syndrome (gis). there are no sufficient data regarding clinical course and treatment options of gis in paediatric patients. ## Methods: A retrospective study of all children with failed renal allografts treated in schneider's children medical center of israel during a 10-year period was conducted. diagnosis of gis was based on clinical criteria and persistence of renal perfusion according to radio-isotopic scan. ## Results: Twenty children with failed renal allografts were studied. the mean age at transplantation was 10.3 +/- 4.9 years. the mean graft survival was 2.9 +/- 2.5 years. two grafts were removed immediately due to vascular complications. of the 18 patients with transplants remaining in situ, 11 (61%) developed gis within 2.7 +/- 2.1 months after restarting dialysis. gis manifestations included fever (91%), local tenderness (82%), hypertension (73%), abdominal pain (64%), macroscopic haematuria (27%), pulmonary congestion (27%) and enlargement of the graft (18%). laboratory findings included anaemia, hypoalbuminaemia and elevated esr and crp. three patients were succ

Who reads Graft Intolerance Syndrome in Children with Failed Kidney Allografts--clinical Presentation, Treatment Options and Outcome?

Author

I. Krause; R. Cleper; A. Belenky; E. Atar; N. Bar-Nathan; M. Davidovits

Publisher

Oxford University Press (OUP)

Published

2008

Language

EN

Field

Medicine (Health Sciences)