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Layer-by-layer Assembly of Polysaccharide-based Nanostructured Surfaces Containing Polyelectrolyte Complex Nanoparticles by Soheil Boddohi; Jorge Almodóvar; Hao Zhang; Patrick A. Johnson; Matt J. Kipper is a Materials Science article available to read on EtoBox.

What is Layer-by-layer Assembly of Polysaccharide-based Nanostructured Surfaces Containing Polyelectrolyte Complex Nanoparticles about?

Nanoscale chemical and topographical features have been demonstrated to influence a variety of significant responses of mammalian cells to biomaterials surfaces. Thus, an important goal for biomaterials scientists is the ability to engineer the nanoscale surface features of biologically active materials. The goal of the current work is to demonstrate that polyelectrolyte complex nanoparticles (PCNs) in polyelectrolyte multilayers (PEMs) can be combined to create surfaces with controlled nanoscale surface topography and nanoscale presentation of surface chemistry. The polysaccharides used in this work are the biomedically relevant chitosan, heparin, and hyaluronan. Nanostructured surface coatings were characterized on both modified gold substrates and tissue-culture polystyrene surfaces. PCNs were adsorbed to oppositely charged PEMs, and were also embedded within PEMs. The construction of the surface coatings was characterized by quartz crystal microbalance with dissipation (QCM-D). The surface morphology was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The chemistry of the coatings was confirmed by both X-ray photoelectron spectroscopy (XPS

Who reads Layer-by-layer Assembly of Polysaccharide-based Nanostructured Surfaces Containing Polyelectrolyte Complex Nanoparticles?

Author

Soheil Boddohi; Jorge Almodóvar; Hao Zhang; Patrick A. Johnson; Matt J. Kipper

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2010

Language

EN

Field

Materials Science (Physical Sciences)