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Effect of Insulin on Small Intestinal Transit in Normal Mice Is Independent of Blood Glucose Level by Krishna Peddyreddy Murali Reddy; Steven Aibor Dkhar; Ramaswamy Subramanian is a Medicine article available to read on EtoBox.

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## Background Insulin is the drug of choice in the management of diabetes mellitus (DM). About 76 % of diabetic patients suffer from gastrointestinal (GI) disorders. Therapy of DM with insulin primarily involves lowering of elevated blood glucose levels. Hence, on any organ in addition to insulin's effect, hypoglycaemic effect also prevails. A systematic study exploring the effect of insulin on small intestinal transit in normal laboratory animals is lacking. Hence, in the present study, the possible effect of insulin with or without associated hypoglycaemia on small intestinal transit in normal mice was examined. ## Results Insulin in all the doses tested (2 μ, 2 m and 2 U/kg) elicited a significant acceleration of SIT. The lower doses of insulin (2 μ and 2 m U/kg) produced significant acceleration of SIT and were associated with normal blood glucose levels. However, the highest dose of insulin (2 U/kg) produced an acceleration of SIT that was associated with significant fall in blood glucose levels. Further, the 2 m and 2 U doses of insulin significantly elevated serum insulin and C-peptide levels. ## Conclusion Insulin at the lowest dose produced an acceleratory effect on SIT th

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Author

Krishna Peddyreddy Murali Reddy; Steven Aibor Dkhar; Ramaswamy Subramanian

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-2012.; Springer Science and Business Media LLC (ISSN 1471-2210)

Published

2006

Language

EN

Field

Medicine (Life Sciences)