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The high-affinity zinc-uptake system znuACB is under control of the iron-uptake regulator ( fur ) gene in the animal pathogen Pasteurella multocida by M.Elena Garrido; Montserrat Bosch; Ricardo Medina; Montserrat Llagostera; Ana M. Pérez de Rozas; Ignacio Badiola; Jordi Barbé is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The Pasteurella multocida znuACB genes encoding a high-affinity zinc-uptake system have been identified and cloned. In contrast to what happens in Escherichia coli, znuA is not physically linked to znuCB. Through lacZ transcriptional fusions it has been demonstrated that zinc negatively regulates both znuA and znuCB operons. Nevertheless, and contrary to that determined so far for all other znuACB bacterial systems known, P. multocida znuACB genes are not under control of the zur gene, which is absent in this bacterial species, but rather are under its iron-uptake regulator (fur) gene. Furthermore, construction of defective mutants has demonstrated that P. multocida znuA and znuCB transcriptional units are required for virulence of this organism in a mouse model.

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Author

M.Elena Garrido; Montserrat Bosch; Ricardo Medina; Montserrat Llagostera; Ana M. Pérez de Rozas; Ignacio Badiola; Jordi Barbé

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0378-1097)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)