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Dopamine Alleviated Acute Liver Injury Induced by Lipopolysaccharide/ D -Galactosamine in Mice by Honghong Zhou; Li Tang; Yongqiang Yang; Ling Lin; Jie Dai; Pu Ge; Qing Ai; Rong Jiang; Li Zhang is a Immunology and Microbiology article available to read on EtoBox.

What is Dopamine Alleviated Acute Liver Injury Induced by Lipopolysaccharide/ D -Galactosamine in Mice about?

Dopamine (DA), a crucial neurotransmitter, not only functions in the central nervous system but also plays important roles in the modulation of inflammation. Several studies suggest that DA might suppress the inflammatory response both in vitro and in vivo. In the present study, the potential effects of DA in a mouse model with lipopolysaccharide (LPS)/d-galactosamine (D-Gal)-induced acute liver injury were investigated. The results show that DA-treated LPS/D-Gal-exposed mice had reduced incidence of histologic lesions, lower plasma aminotransferases and improved the survival rates compared to LPS/D-Gal-exposed mice. Treatment with DA also suppressed LPS/D-Gal-induced production of TNF-α, phosphorylation of c-jun-N-terminal kinase (JNK), cleavage of caspase-3, up-regulation of hepatic caspase-3, caspase-8, and caspase-9 activities and reduced the count of TUNEL-positive hepatocytes. These data indicate that DA attenuated LPS/D-Gal-induced fulminant liver injury in mice, which implies that DA might have value for the prevention of inflammatory liver disease.

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Author

Honghong Zhou; Li Tang; Yongqiang Yang; Ling Lin; Jie Dai; Pu Ge; Qing Ai; Rong Jiang; Li Zhang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-5769)

Published

2018

Language

EN

Field

Immunology and Microbiology (Life Sciences)