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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies by Daniel Wrapp, Dorien De Vlieger, Kizzmekia S. Corbett, Bert Schepens, Xavier Saelens, Jason S. McLellan is a nonfiction available to read on EtoBox.

What is Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies about?

Using llamas immunized with prefusionstabilized betacoronavirus spike proteins, Wrapp et al. identify neutralizing cross-reactive single-domain camelid antibodies, which may serve not only as useful reagents for researchers studying the viruses causing MERS, SARS, and SARS-CoV-2, but also potential therapeutic candidates. Crystal structures further reveal how these antibodies bind spike proteins to prevent virus entry into cells. VHHs isolated from a llama immunized with prefusionstabilized coronavirus spikes Structural characterization of VHHs reveals conserved mechanism of neutralization SARS-CoV-1 S-directed VHH cross-reacts with SARS-CoV- 2 S Bivalent VHH neutralizes SARS-CoV-2 pseudoviruses

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Author

Daniel Wrapp, Dorien De Vlieger, Kizzmekia S. Corbett, Bert Schepens, Xavier Saelens, Jason S. McLellan

Publisher

Cell Journal

Published

2020

Language

EN

Category

nonfiction