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Molecular Dynamics Simulations for the Study of Chromatin Biology by Giovanni B. Brandani; Soundhararajan Gopi; Masataka Yamauchi; Shoji Takada is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular Dynamics Simulations for the Study of Chromatin Biology about?

The organization of Eukaryotic DNA into chromatin has profound implications for the processing of genetic information. In the past years, molecular dynamics (MD) simulations proved to be a powerful tool to investigate the mechanistic basis of chromatin biology. We review recent all-atom and coarse-grained MD studies revealing how the structure and dynamics of chromatin underlie its biological functions. We describe the latest method developments; the structural fluctuations of nucleosomes and the various factors affecting them; the organization of chromatin fibers, with particular emphasis on its liquid-like character; the interactions and dynamics of transcription factors on chromatin; and how chromatin organization is modulated by molecular motors acting on DNA.

Who reads Molecular Dynamics Simulations for the Study of Chromatin Biology?

Author

Giovanni B. Brandani; Soundhararajan Gopi; Masataka Yamauchi; Shoji Takada

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)