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JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos by Katerina Karkali; Timothy E. Saunders; George Panayotou; Enrique Martín-Blanco is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos about?

## Abstract Morphogenesis of the Central Nervous System (CNS) is a complex process that obeys precise architectural rules. Yet, the mechanisms dictating these rules remain unknown. Analyzing morphogenesis of the Drosophila embryo Ventral Nerve Cord (VNC), we observe that a tight control of JNK signaling is essential for attaining the final VNC architecture. JNK signaling in a specific subset of pioneer neurons autonomously regulates the expression of Fasciclin 2 (Fas 2) and Neurexin IV (Nrx IV) adhesion molecules, probably via the transcription factor zfh1. Interfering at any step in this cascade affects fasciculation along pioneer axons, leading to secondary cumulative scaffolding defects during the structural organization of the axonal network. The global disorder of architectural landmarks ultimately influences nervous system condensation. In summary, our data point to JNK signaling in a subset of pioneer neurons as a key element underpinning VNC architecture, revealing critical milestones on the mechanism of control of its structural organization.

Who reads JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos?

Author

Katerina Karkali; Timothy E. Saunders; George Panayotou; Enrique Martín-Blanco

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)