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Activity of Antimicrobial Peptides in the Presence of Polysaccharides Produced by Pulmonary Pathogens by M. Benincasa; M. Mattiuzzo; Y. Herasimenka; P. Cescutti; R. Rizzo; R. Gennaro is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Antimicrobial peptides (AMPs) are secreted in the airway and contribute to initial defence against inhaled pathogens. Infections of the respiratory tract are a major cause of morbidity and mortality in preterm newborns and in patients with cystic fibrosis (CF). In this latter group, the state of chronic lung infection is due to the ability of bacteria to grow as mucoid biofilm, a condition characterised by overproduction and release of polysaccharides (PSs). In this study, we investigate the effect of PSs produced by lung pathogens such as __Pseudomonas aeruginosa, Klebsiella pneumoniae__ and members of the __Burkholderia cepacia__ complex on the antibacterial activity of structurally different peptides. The AMPs tested in this study include the cathelicidin LL‐37 and the β‐defensin hBD‐3 from humans, both released at the alveolar level, as well as peptides from other mammals, i.e. SMAP‐29, PG‐1 and Bac7(1‐35). Susceptibility assays, time killing and membrane permeabilization kinetics experiments were carried out to establish whether PSs produced by lung pathogens may be involved in the poor defence reaction of infected lungs and thus explain infection persistence. All

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Author

M. Benincasa; M. Mattiuzzo; Y. Herasimenka; P. Cescutti; R. Rizzo; R. Gennaro

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-2617)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)