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Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response by Israr Khan; Junshu Wei; Anping Li; Zhirong Liu; Pingrong Yang; Yaping Jing; Xinjun Chen; Tang Zhao; Yanrui Bai; Lajia Zha; Chenhui Li; Naeem Ullah; Tuanjie Che; Chunjiang Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response about?
Gut microbiota has become a new therapeutic target in the treatment of inflammatory Bowel Disease (IBD). Probiotics are known for their beneficial effects and have shown good efficacy in the clinical treatment of IBD and animal models of colitis. However, how these probiotics contribute to the amelioration of IBD is largely unknown. In the current study, the DSS-induced mouse colitis model was treated with oral administration of Lactobacillus plantarum strains to investigate their effects on colitis. The results indicated that the L. plantarum strains improved dysbiosis and enhanced the abundance of beneficial bacteria related to short-chain fatty acids (SCFAs) production. Moreover, L. plantarum strains decreased the level of pro-inflammatory cytokines, i.e., IL-17A, IL-17F, IL-6, IL-22, and TNF-α and increased the level of anti-inflammatory cytokines, i.e., TGF-β, IL-10. Our result suggests that L. plantarum strains possess probiotic effects and can ameliorate DSS colitis in mice by modulating the resident gut microbiota and immune response.
Who reads Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Israr Khan; Junshu Wei; Anping Li; Zhirong Liu; Pingrong Yang; Yaping Jing; Xinjun Chen; Tang Zhao; Yanrui Bai; Lajia Zha; Chenhui Li; Naeem Ullah; Tuanjie Che; Chunjiang Zhang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)