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Molecular Markers for Prognosis After Isolated Postmastectomy Chest Wall Recurrence by Bruce G. Haffty; Analene Hauser; Doo Ho Choi; Nicole Parisot; David Rimm; Bonnie King; Darryl Carter is a Medicine article available to read on EtoBox.

What is Molecular Markers for Prognosis After Isolated Postmastectomy Chest Wall Recurrence about?

## Abstract ## BACKGROUND Local chest wall recurrence after mastectomy occurs in 10–20% of patients with operable breast carcinoma. The objective of the current study was to assess the prognostic value of molecular markers at the time of local recurrence and to compare these markers with clinical variables. ## METHODS Between 1975 and 1999, the authors treated 113 patients at their institution for postmastectomy chest wall recurrences with full‐course external beam radiotherapy. Patients who presented primarily with lymph node recurrences or with simultaneous distant metastasis were excluded. Follow‐up from the time of chest wall recurrence was 10.13 years. All clinical and pathologic data from the original diagnosis and from the time of chest wall recurrence were entered into a computerized database. Paraffin‐embedded tumor specimens from the chest wall recurrences were available for 43 patients and were constructed into tissue microarrays for immunohistochemical staining of estrogen receptor, progesterone receptor (PR), p53, HER‐2/neu, and cyclin D. ## RESULTS Overall survival after chest wall recurrence for the entire cohort was 46% at 5 years and 28% at 10 years. The distant me

Who reads Molecular Markers for Prognosis After Isolated Postmastectomy Chest Wall Recurrence?

Author

Bruce G. Haffty; Analene Hauser; Doo Ho Choi; Nicole Parisot; David Rimm; Bonnie King; Darryl Carter

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2004

Language

EN

Field

Medicine (Health Sciences)