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What is Patronin Stabilizes Microtubule Minus Ends about?

Patronin is a protein that stabilizes microtubule minus ends and protects them from depolymerization. Goodwin and Vale found that Patronin selectively binds to minus ends in vivo and in vitro, shielding them from the depolymerase Kinesin-13. Without Patronin, microtubule organization is defective during interphase and mitosis, indicating that stabilizing and destabilizing proteins regulate microtubule minus ends dynamics similarly to plus ends.

Author

Sergio Uribe

Language

EN