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Can I read Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help on EtoBox?
Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help by Adam Gulbranson-Judge; Victor L. J. Tybulewicz; Alice E. Walters; Kai-Michael Toellner; Ian C. M. MacLennan; Martin Turner is a Immunology and Microbiology article available to read on EtoBox.
What is Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help about?
Vav, a guanine nucleotide exchange factor for members of the Rho family of small GTPases, is activated through engagement of B and T lymphocyte antigen receptors. It is important for establishing the signaling threshold of the TCR, as mice lacking Vav display defective thymocyte selection. Here, conventional B cells are shown to develop normally in Vav-deficient mice but these mice have few B-1 B cells. The threshold for inducing B cell proliferation through BCR engagement in vitro is greater in Vav-deficient B cells. Nevertheless, in vivo the mutant mice have normal antibody responses to haptenated Ficoll. In contrast, Vav-/- mice show defective class switching to IgG and germinal center formation when immunized with haptenated protein. Interestingly, this defect is reversed in chimeras where normal T cells are present. Antigen-specific proliferation of T cells in the T zone was found to be similar in wild-type and Vav-/- mice but the induction of IL-4 mRNA and switch transcripts was specifically impaired. These results suggest that defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help.
Who reads Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Adam Gulbranson-Judge; Victor L. J. Tybulewicz; Alice E. Walters; Kai-Michael Toellner; Ian C. M. MacLennan; Martin Turner
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)
- Published
- 1999
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)