Can I read Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer on EtoBox?

Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer by Inamori, Koji (author);Togashi, Yosuke (author);Fukuoka, Shota (author);Akagi, Kiwamu (author);Ogasawara, Kouetsu (author);Irie, Takuma (author);Motooka, Daisuke (author);Kobayashi, Yoichi (author);Sugiyama, Daisuke (author);Kojima, Motohiro (author);Shiiya, Norihiko (author);Nakamura, Shota (author);Maruyama, Shoichi (author);Suzuki, Yutaka (author);Ito, Masaaki (author);Nishikawa, Hiroyoshi (author) is a Immunology and Microbiology article available to read on EtoBox.

What is Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer about?

Patients with colorectal cancers (CRCs) generally exhibit improved survival through intensive lymph node (LN) dissection. However, recent progress in cancer immunotherapy revisits the potential importance of regional LNs, where T cells are primed to attack tumor cells. To elucidate the role of regional LN, we investigated the immunological status of nonmetastatic regional LN lymphocytes (LNLs) in comparison with those of the tumor microenvironment (tumor-infiltrating lymphocytes; TILs) using flow cytometry and next-generation sequencing. LNLs comprised an intermediate level of the effector T cell population between peripheral blood lymphocytes (PBLs) and TILs. Significant overlap of the T cell receptor (TCR) repertoire was observed in microsatellite instability–high/mismatch repair–deficient (MSI-H/dMMR) CRCs with high tumor mutation burden (TMB), although limited TCRs were shared between nonmetastatic LNs and primary tumors in microsatellite stable/MMR proficient (MSS/pMMR) CRC patients with low TMB. In line with the overlap of the TCR repertoire, an excessive LN dissection did not provide a positive impact on long-term prognosis in our MSI-H/dMMR CRC cohort (__n__ = 130). We prop

Who reads Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer?

Author

Inamori, Koji (author);Togashi, Yosuke (author);Fukuoka, Shota (author);Akagi, Kiwamu (author);Ogasawara, Kouetsu (author);Irie, Takuma (author);Motooka, Daisuke (author);Kobayashi, Yoichi (author);Sugiyama, Daisuke (author);Kojima, Motohiro (author);Shiiya, Norihiko (author);Nakamura, Shota (author);Maruyama, Shoichi (author);Suzuki, Yutaka (author);Ito, Masaaki (author);Nishikawa, Hiroyoshi (author)

Publisher

American Society for Clinical Investigation

Published

2021

Language

EN

Field

Immunology and Microbiology (Life Sciences)