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Can I read Ketamine-induced Hippocampal Functional Connectivity Alterations Associated with Clinical Remission in Major Depression on EtoBox?
Ketamine-induced Hippocampal Functional Connectivity Alterations Associated with Clinical Remission in Major Depression by Fan Zhang; Chengyu Wang; Xiaofeng Lan; Weicheng Li; Yanxiang Ye; Haiyan Liu; Zhibo Hu; Zerui You; Yanling Zhou; Yuping Ning is a Psychology article available to read on EtoBox.
What is Ketamine-induced Hippocampal Functional Connectivity Alterations Associated with Clinical Remission in Major Depression about?
Objective Hippocampal functional connectivity (FC) alterations, which may happen following ketamine treatment, play a key role in major depression remission. This study aims to investigate the resting-state FC changes of the hippocampus associated with clinical remission after repeated ketamine infusions. Methods Forty-four major depressive patients received six intravenous ketamine (0.5 mg/kg) infusions in 12 days. The FC change of the hippocampus subregions following ketamine treatment was compared between remitters (MADRS score ≤ 10 post-treatment) and nonremitters. We also investigated whether baseline hippocampus FC predicted the antidepressant efficiency of ketamine using Receiver Operating Characteristic Curve analyses. Results Thirty-nine patients were included in the analysis. There were significant differences in change of left rostral hippocampus FC with the right angular gyrus (the key node of the default mode network, DMN), left inferior parietal cortex and the right superior parietal cortex (parts of the dorsal attention network, dAN) between remitters and nonremitters following ketamine treatment. Specifically, while the remitters showed significantly less negative h
Who reads Ketamine-induced Hippocampal Functional Connectivity Alterations Associated with Clinical Remission in Major Depression?
It is typically read by researchers, students, and practitioners in Psychology.
- Author
- Fan Zhang; Chengyu Wang; Xiaofeng Lan; Weicheng Li; Yanxiang Ye; Haiyan Liu; Zhibo Hu; Zerui You; Yanling Zhou; Yuping Ning
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Psychology (Social Sciences)