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Leukotriene receptor antagonist use and cognitive decline in normal cognition, mild cognitive impairment, and Alzheimer’s dementia by Lisa Y. Xiong; Michael Ouk; Che-Yuan Wu; Jennifer S. Rabin; Krista L. Lanctôt; Nathan Herrmann; Sandra E. Black; Jodi D. Edwards; Walter Swardfager is a Medicine article available to read on EtoBox.
What is Leukotriene receptor antagonist use and cognitive decline in normal cognition, mild cognitive impairment, and Alzheimer’s dementia about?
## Abstract ## Background Leukotriene receptor antagonists (LTRAs) alleviate Alzheimer’s disease (AD) pathology and improve cognition in animal models; however, clinical evidence is limited. This study aimed to explore the associations between the use of LTRAs (montelukast or zafirlukast) and cognitive performance in people with normal cognition, mild cognitive impairment (MCI), or AD dementia. We hypothesized that LTRA use would be associated with better cognitive performance over time. ## Methods This longitudinal observational study used data from the National Alzheimer’s Coordinating Center. Within groups of participants with normal cognition, MCI, or AD dementia, LTRA users were matched 1:3 to non-users using propensity score matching. Cognitive domains including immediate and delayed memory (Wechsler Memory Scale Revised-Logical Memory IA and IIA), psychomotor processing speed (Digit Symbol Substitution Test), and language (animal naming, vegetable naming, and Boston Naming Test) were compared between users and non-users in mixed-effects linear or Poisson regression models. ## Results In AD dementia, LTRA use was associated with a slower decline in psychomotor processing spee
Who reads Leukotriene receptor antagonist use and cognitive decline in normal cognition, mild cognitive impairment, and Alzheimer’s dementia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lisa Y. Xiong; Michael Ouk; Che-Yuan Wu; Jennifer S. Rabin; Krista L. Lanctôt; Nathan Herrmann; Sandra E. Black; Jodi D. Edwards; Walter Swardfager
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)