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Analysis of Central Cardioarrhythmogenic Triggers in Experimental Epilepsy by O. Mameli; P. Mameli; E. Tolu; G. Padua; F. Melis; M.A. Caria; A. Virdis is a Medicine article available to read on EtoBox.

What is Analysis of Central Cardioarrhythmogenic Triggers in Experimental Epilepsy about?

The cardioarrhythmogenic potential of epileptic foci induced at mesencephaiic and rhombencephalic levels was analysed in hemispherectomized rats. Topical application of penicillin-t3 onto the mesencephalic quadrigeminal lamina or onto the fourth ventricle induced paroxysmal activity at the mesencephalic or bulbar neurone level. At the mesencephalic levels, the paroxysmal activity was characterized by a significant increase in the spontaneous frequency of the neurones, with the appearance of multiunit activity and rhythmical outbursts. The simultaneous recording of myocardial electrical activity and blood pressure showed that the paroxysmal activity triggered short-latency sinus bradyarrhythmias with wandering of the sinus pacemaker, the appearance of biphasic or negative P waves, some premature ventricular contractions and non-significant reduction of systolic and diastolic pressures. When the paroxysmal activity stopped, the cardiac rhythm and blood pressure returned to basal values. At the bulbar level, the paroxysmal activity appeared with longer latency and usually the rhythmical outbursts were not observed. Following bulbar paroxysmal activity only short-lasting episodes of si

Who reads Analysis of Central Cardioarrhythmogenic Triggers in Experimental Epilepsy?

Author

O. Mameli; P. Mameli; E. Tolu; G. Padua; F. Melis; M.A. Caria; A. Virdis

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

1990

Language

EN

Field

Medicine (Health Sciences)