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The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis by Chao Luo; Shunlin Peng; Mao Li; Xudong Ao; Zhiqing Liu is a Immunology and Microbiology article available to read on EtoBox.

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## Background Probiotics have proven beneficial in a number of immune-mediated and allergic diseases. Several human studies have evaluated the efficacy and safety of probiotics in allergic rhinitis; however, evidence for their use has yet to be firmly established. ## Objective We undertook a systematic review and meta-analysis aiming to address the effect and safety of probiotics on allergic rhinitis. ## Methods We systematically searched databases [MEDLINE (PubMed), Embase, and the Cochrane Central Register of Controlled Trials] from inception until June 1, 2021. Qualified literature was selected according to inclusion and exclusion criteria, the data were extracted, and a systematic review and meta-analysis was conducted. ## Results Twenty-eight studies were included. The results showed that probiotics significantly relieved allergic rhinitis symptoms (standardized mean difference [SMD], −0.29, 95% confidence interval (CI) [−0.44, −0.13]; __p__ = 0.0003, __I__ ^2^ = 89%), decreased Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores compared with the control group (SMD, −0.64, 95% CI [−0.79, −0.49], __p__ < 0.00001, __I__ ^2^ = 97%), and increased T helper cell 1(Th1)

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Author

Chao Luo; Shunlin Peng; Mao Li; Xudong Ao; Zhiqing Liu

Published

2022

Language

EN

Field

Immunology and Microbiology (Life Sciences)