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Stability of Phospholipid Vesicles Studied by Asymmetrical Flow Field-flow Fractionation and Capillary Electrophoresis by Gebrenegus Yohannes; Kati-Henna Pystynen; Marja-Liisa Riekkola; Susanne K. Wiedmer is a Chemistry article available to read on EtoBox.
What is Stability of Phospholipid Vesicles Studied by Asymmetrical Flow Field-flow Fractionation and Capillary Electrophoresis about?
The stability of zwitterionic phosphatidylcholine vesicles in the presence of 20 mol% phosphatidyl serine (PS), phosphatidic acid (PA), phosphatidyl inositol (PI), and diacylphosphatidyl glycerol (PG) phospholipid vesicles, and cholesterol or calcium chloride was investigated by asymmetrical flow field-flow fractionation (AsFlFFF). Large unilamellar vesicles (LUV, diameter 100 nm) prepared by extrusion at 25 • C were used. Phospholipid vesicles (liposomes) were stored at +4 and -18 • C over an extended period of time. Extruded egg yolk phosphatidylcholine (EPC) particle diameters at peak maximum and mean measured by AsFlFFF were 101 ± 3 nm and 122 ± 5 nm, respectively. No significant change in diameter was observed after storage at +4 • C for about 5 months. When the storage period was extended to about 8 months (250 days) larger destabilized aggregates were formed (172 and 215 nm at peak maximum and mean diameters, respectively). When EPC was stored at -18 • C, large particles with diameters of 700-800 nm were formed as a result of dehydration, aggregation, and fusion processes. In the presence of calcium chloride, EPC alone did not form large aggregates. Addition of 20 mol% of ne
Who reads Stability of Phospholipid Vesicles Studied by Asymmetrical Flow Field-flow Fractionation and Capillary Electrophoresis?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Gebrenegus Yohannes; Kati-Henna Pystynen; Marja-Liisa Riekkola; Susanne K. Wiedmer
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)